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Sodomy A vague term which either means any kind of genital sex other than vaginal intercourse, or any kind of sex a given group or person considers unnatural or sinful. Cimetidine , a nonspecific CYP inhibitor, caused a 56 increase in plasma sildenafil concentrations when coadministered with sildenafil to healthy volunteers. The body then directs PDE 5 to start breaking down the cGMP, which causes blood to flow out of the blood vessels of the penis and end the erection. To ensure clinical relevancy, studies about derivates of sildenafil were also discarded. 2Mitidieri E, Cirino G, d Emmanuele di Villa Bianca R, Sorrentino R Pharmacology and perspectives in erectile dysfunction in man.