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Sildenafil is seen as a quick fix and given as a placebo to treat erectile dysfunction in men with psychological issues and the good news is it can help. These tablets together can cure the condition of Erectile Dysfunction as well as restore the sexual power of a man which further helps him in increasing self worth and confidence. You will probably take sildenafil three times a day with or without food. Secobarbital will decrease the level or effect of sildenafil by affecting hepatic intestinal enzyme CYP3A4 metabolism. In in vitro studies, sildenafil was shown to potentiate the anti aggregatory effect of the nitric oxide donor, sodium nitroprusside.